S. Karlsson Group Our ResearchWe are studying the regulation of hematopoietic stem cells (HSCs) in order to understand how signaling pathways, transcriptional mechanisms and epigenetic regulators govern stem cell behavior to determine stem cell fate options.Integrative signaling and transcriptional networks act in concert to determine whether hematopoietic stem cells remain quiescent, proliferate

https://www.stemcellcenter.lu.se/research-groups/skarlsson - 2025-01-14

Kokaia group AimBy linking together basic and clinical research, we aim to clarify cellular mechanisms of regeneration following damage to the brain and develop new therapeutic strategies to restore function in this organ (primarily in stroke and Parkinson’s disease) by transplantation of stem cells or reprogrammed cells and optimization of endogenous repair mechanisms.  Our ResearchAvailable expe

https://www.stemcellcenter.lu.se/research-groups/laboratory-stem-cells-and-restorative-neurology - 2025-01-14

Larsson Group Our researchThe focus of the research in the Larsson group is to define genes and pathways that regulate human hematopoietic stem cells (HSCs) and to develop novel strategies for ex vivo stem cell expansion to enhance current cell therapies of hematological disorders. Over the last few years the laboratory has developed strategies to screen for modifiers of self-renewal/proliferation

https://www.stemcellcenter.lu.se/research-groups/larsson - 2025-01-14

Researchers at Lund University already have a strong international position in two major areas of somatic stem cell and cell therapy research: Neural cell replacement therapies for central nervous system (CNS) disorders Hematopoietic stem cell (HSC) biology and gene therapyThe sections of Neurobiology and Restorative Neurology have an internationally leading position in CNS disease models and expe

https://www.stemcellcenter.lu.se/research - 2025-01-14

Artner Group Our Research Diabetes results from loss or dysfunction of insulin producing beta cells in the pancreas. Despite insulin injection treatment, diabetic patients suffer from long-term complications, such as blindness and kidney failure. Therefore, a central goal of diabetes research is to regenerate pancreatic beta cells or produce large numbers of functional beta cells for transplantati

https://www.stemcellcenter.lu.se/research-groups/artner - 2025-01-14

Pera Group Our Research  In our research, we are studying extracellular signals in embryonic development and cancer. Particular emphasis is given to mechanisms that regulate pattern formation and collective cell migration in the vertebrate embryo. The neural crest is a multipotent and highly motile cell population that arises at the border of the neural plate, delaminates and colonizes a wide vari

https://www.stemcellcenter.lu.se/research-groups/pera - 2025-01-14

Pronk Group Our ResearchToday, we cure about 85% of children with cancer. In some subgroups, such as acute lymphoblastic leukemia (ALL), cure rates exceed 90%. Treating pediatric cancer patients is characterized by balancing of anti-tumor actions with treatment related morbidity/mortality. Many patients suffer from treatment toxicities during or following completion of treatment, sometime with a l

https://www.stemcellcenter.lu.se/research-groups/pronk - 2025-01-14

Rönnstrand Group Our ResearchThe focus of our laboratory is to understand the molecular mechanisms of cancer, specifically acute leukemia and malignant melanoma. In particular, in acute myeloid leukemia, oncogenic mutations in the receptor tyrosine kinase FLT3 is commonly occurring and correlates with poor prognosis of patients. For this reason, several selective inhibitors of FLT3 have been devel

https://www.stemcellcenter.lu.se/research-groups/ronnstrand - 2025-01-14

Scheding Group Our researchHuman bone marrow (BM) contains the hematopoietic stem cells (HSC) as well as a rare population of non-hematopoietic bone marrow stromal stem cells (BMSC). The HSCs are responsible for the life-long production of the different blood cells, whereas BMSCs generate skeletal tissues and give rise to the hematopoietic microenvironment (HME).HSC and BMSC closely interact with

https://www.stemcellcenter.lu.se/research-groups/scheding - 2025-01-14

Soneji Group Thousands of single-cells can be profiled using next generation sequencing technologies, and this leads to a massive amount of data which needs processing and analysing to determine the underlying biology of the samples assayed. Key to this is data visualisation, and a common step is to generate "maps" of cells which make the data human-comprehensible. The maps are often constructed i

https://www.stemcellcenter.lu.se/research-groups/soneji - 2025-01-14

Wagner Group Our research  Over three million people die each year and over 60 million people suffer worldwide from chronic lung diseases (CLDs). Currently, there is no cure for CLDs, including chronic obstructive pulmonary disease (COPD), pulmonary hypertension, and pulmonary fibrosis. Lung transplantation is the only option at end-stage disease and is further complicated by shortage in organs av

https://www.stemcellcenter.lu.se/research-groups/wagner - 2025-01-14

Woods Group Our ResearchHematopoietic stem cells (HSCs) are rare cells in the body that possess the ability to generate vast numbers of a multitude of specialised blood cell types required for our survival. HSCs are first generated in the early embryo and undergo a series of maturation processes that ultimately give rise to their key adult features of self-renewal, blood cell generation, and trans

https://www.stemcellcenter.lu.se/research-groups/woods - 2025-01-14

Miharada Group Our Research Many of biological activities in cells, for example differentiation and proliferation, are regulated at different levels. In addition to the classical “Central dogma” flow (DNA to RNA to protein), modification of proteins and metabolic change could critically affect cellular character and fate. Stem cells – having self-renewal capacity and multi-lineage differentiation

https://www.stemcellcenter.lu.se/research-groups/miharada - 2025-01-14

Novel Conceptual Advances in the field of Stem Cell Biology Tuesday 15th December 2015, Belfrage Lecture Hall, BMC D15 Invited speakers:Jianlong Sun, PhD. Department of Stem Cell and Regenerative Biology, Harvard University USA, "The inner workings of native hematopoiesis revealed by transposon-mediated cellular barcoding"Disa Tehler, PhD. Biotech Research & Innovation Centre (BRIC), Copenhagen "C

https://www.stemcellcenter.lu.se/lund-stem-cell-center/young-investigator-symposium/young-investigator-symposium-2015 - 2025-01-14

Novel Conceptual Advances in the field of stem cell biology Thursday 19th January 2017, Belfrage Lecture Hall, BMC D15 Invited speakers:Noelia Urbán, PhD, Francis Crick Institute, UK´, "Return to quiescence of mouse neural stem cells by degradation of a proactivation protein"Leslie Crews, PhD, Moores Cancer Center & Stanford Consortium for Regenerative Medicine, USA, "RNA Splicing Modulation Selec

https://www.stemcellcenter.lu.se/lund-stem-cell-center/young-investigator-symposium/young-investigator-symposium-2017 - 2025-01-14

Advances in stem cell research: applications of novel techniques Tuesday 17th April 2018, Belfrage Lecture Hall, BMC D15 Invited speakers:Lluc Mosteiro, PhD, Genentech, San Francisco, USA"Tissue damage and senescence provide critical signals for cellular reprogramming in vivo”Giorgia Quadrato, PhD, Harvard Department of Stem Cell and Regenerative Biology, Harvard University, USA"Cell diversity and

https://www.stemcellcenter.lu.se/lund-stem-cell-center/young-investigator-symposium/young-investigator-symposium-2018 - 2025-01-14

Bellodi Group Our ResearchRibonucleic acid or RNA, one of life’s indispensable molecules, governs the flow of the genetic information within cells. Our laboratory focuses on new facets of gene expression control in stem and cancer cell at a molecular, cellular and organismal level. Using hematopoiesis as a model system to study stem cell function, we combine innovative genetic models with state-of

https://www.stemcellcenter.lu.se/research-groups/bellodi - 2025-01-14

Novel concepts and technologies in Stem Cell Biology Tuesday 4th June 2019, Belfrage Lecture Hall, BMC D15 Invited speakers:Alessandro Fantin, PhD. Univesity of Milan, Italy: “Erythro-myeloid progenitors contribute endothelial cells to blood vessels”Dena Leeman, PhD. Genentech, USA: “Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging”Bastiaan Span

https://www.stemcellcenter.lu.se/lund-stem-cell-center/young-investigator-symposium/young-investigator-symposium-2019 - 2025-01-14

13 March 2015 During the European UniStem Day, March 13th, 2015, students from high schools in Lund were invited to visit stem cell researchers at Lund University. UniStem Day is held every year in various European countries and is a part of a broader initiative within the EU to increase young people's knowledge about stem cell research.   When UniStem Day was organized for the first time by the S

https://www.stemcellcenter.lu.se/research-school/program-overview/public-engagement/unistem2015 - 2025-01-14

Undergraduate Education Board Research Studies Board Future Faculty Board Programme boards International committees International council

https://www.intramed.lu.se/en/organisation-and-governance/boards-and-committees/education - 2025-01-14