Search results

Filter

Filetype

Your search for "*" yielded 128952 hits

Klimatförändringar – digital lärresurs

Årskurs: 7-9, Gymnasiet En digital undervisningssekvens (på norska) för att lära sig om klimatets fysik och träna på att delta i samtal om klimatförändringar samt bidra till att hitta lösningar. Materialet har utvecklats av Naturfagsenteret, CICERO Senter for klimaforsking, NAROM og Utdanningsetaten i Oslo.  Ta del av lärresursen om klimatförändringar på Naturfagsenterets hemsida (ny flik)  

https://www.nrcf.lu.se/lararresurser/att-arbeta-med-samhallsfragor/klimatforandringar-digital-larresurs - 2025-12-25

Expedition till Mars

Årskurs: 4-6, 7-9, Gymnasiet Undervisningsmaterialet om en rymdexpedition till Mars har översatts och bearbetats av NRCF utifrån det brittiska originalet ”Mars Mission Debate Kit”. Detta debattunderlag har framgångsrikt använts av elever i åldrarna 11-18 år. Materialet innehåller åtta rollkort, detaljerad lektionsplanering med mera. Fråga Borde vi skicka en mänsklig rymdexpedition till Mars? Intro

https://www.nrcf.lu.se/lararresurser/att-arbeta-med-samhallsfragor/expedition-till-mars - 2025-12-25

Rotera mera

Årskurs: 7-9, Gymnasiet Ämnesområde: Kraft och rörelse Om hur konståkare, simhoppare och gymnaster sätter snurr på tillvaron. Du har säkert sett en konståkare göra piruetter på isen. Genom att dra in armar och ben mot kroppen kan hen snabbt öka sin rotationshastighet. Du kan själv experimentera kring detta med hjälp av en vanlig kontorsstol och något tungt i händerna som till exempel tegelstenar.

https://www.nrcf.lu.se/lararresurser/lararresurser-fran-o/p-r/rotera-mera - 2025-12-25

LjUVa sol!

Årskurs: F-3, 4-6 Ämnesområde: Ljus och ljud Med hjälp av så kallade UV-pärlor kan man testa hur effektiva olika solskydd är. Vi kan inte se solens ultravioletta strålar (UV-strålar) men vi märker att de finns där eftersom vi blir solbrända. Med UV-pärlor kan man direkt avgöra var UV-strålarna finns, och hur man skyddar sig mot dem på bästa sätt. Material Två eller flera olika sorters solkräm. En

https://www.nrcf.lu.se/lararresurser/lararresurser-fran-o/j-l/ljuva-sol - 2025-12-25

Blinda fläcken

Årskurs: 4-6, 7-9 Ämnesområde: Ljus och ljud   Ögats näthinna reagerar på det ljus som kommer in i ögat. Näthinnan skickar signaler till hjärnan, detta är att se. Det finns emellertid delar av näthinnan som inte ger dig någon syninformation. Detta är ögats blinda fläck. Med hjälp av nedanstående experiment kan du räkna ut storleken på den blinda fläcken, visa att den finns och hur hjärnan kompense

https://www.nrcf.lu.se/lararresurser/lararresurser-fran-o/d/blinda-flacken - 2025-12-25

Ljusets inverkan på pupillen

Årskurs: 4-6, 7-9 Ämnesområde: Ljus och ljud Din pupill ändrar storlek för att reglera hur mycket ljus som kommer in i ögat. I det här experimentet kan du se hur pupillen ändrar storlek när belysningen ändras. Du kan också se hur ljus som lyser in i det ena ögat påverkar det andra ögats pupillstorlek. Material Ett förstoringsglas (minst 2,5 centimeter i diameter). En spegel (minst 10x10 centimeter

https://www.nrcf.lu.se/lararresurser/lararresurser-fran-o/j-l/ljusets-inverkan-pa-pupillen - 2025-12-25

Sofia Bergh, PhD student

In June 2022, Sofia Bergh started her PhD studies in TNU supervised by Prof. Åsa Petersén. The overall aim of the PhD project is to investigate the cellular and molecular mechanisms of limbic system pathology of Huntington’s disease. Her first original research article is in press titled “Effects of mutant huntingtin in oxytocin neurons on non-motor features of Huntington’s disease” in Neuropathol

https://www.huntington-research.lu.se/team/sofia-bergh-phd-student - 2025-12-25

Thermoregulatory disorders in Huntington disease

Weydt P, Dupuis L and Petersen Å. Handbook of Clinical Neurology 157: 761-775 (2018) Abstract Huntington disease (HD) is a paradigmatic autosomal-dominant adult-onset neurodegenerative disease. Since the identification of an abnormal expansion of a trinucleotide repeat tract in the huntingtin gene as the underlying genetic defect, a broad range of transgenic animal models of the disease has become

https://www.huntington-research.lu.se/thermoregulatory-disorders-huntington-disease - 2025-12-25

Maintenance of Basal Levels of Autophagy in Huntington’s Disease Mouse Models Displaying Metabolic Dysfunction

Baldo B, Soylu R and Petersén ÅPLoS One 8(12) (2013)AbstractHuntington's disease (HD) is a fatal neurodegenerative disorder caused by an expanded polyglutamine repeat in the huntingtin protein. Neuropathology in the basal ganglia and in the cerebral cortex has been linked to the motor and cognitive symptoms whereas recent work has suggested that the hypothalamus might be involved in the metabolic

https://www.huntington-research.lu.se/maintenance-basal-levels-autophagy-huntingtons-disease-mouse-models-displaying-metabolic-dysfunction - 2025-12-25

Effects of mutant huntingtin in oxytocin neurons on non-motor features of Huntington's disease

Bergh S, Gabery S, Tonetto S, Kirik D, Petersén Å and Cheong RY. Neuropathology and Applied Neurobiology. 2023;49(2):e12891. doi:10.1111/nan.12891 [published correction appears in Neuropathol Appl Neurobiol. 2023 Jun;49(3):e12905]. Abstract Background: Early non-motor features including anxiety, depression and altered social cognition are present in Huntington's disease (HD). The underlying neurob

https://www.huntington-research.lu.se/effects-mutant-huntingtin-oxytocin-neurons-non-motor-features-huntingtons-disease - 2025-12-25

Karin Dalene Skarping, PhD student

In May 2022, Karin Dalene Skarping started her PhD studies in TNU supervised by Prof. Åsa Petersén. The overall aim of the PhD project is to study genetic mechanisms that may modify the disease course and pathology of Huntington disease. One of her current research projects is aimed to examine associations between germline pathogenic variants in mismatch-repair (MMR) genes and CAG-repeats in HTT,

https://www.huntington-research.lu.se/team/karin-dalene-skarping-phd-student - 2025-12-25

Hypothalamic expression of mutant huntingtin contributes to the development of depressive-like behavior in the BAC transgenic mouse model of Huntington's disease

Sofia Hult Lundh1, Nathalie Nilsson1, Rana Soylu1, Deniz Kirik2 and Åsa Petersén1.1Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund SE-221 84, Sweden.2Brain Repair and Imaging in Neural Systems (BRAINS) Unit, Department of Experimental Medical Science, Lund University, Lund SE-221 84, Sweden.Human Molecular Genetics 22: 3485-3497 (2013)A

https://www.huntington-research.lu.se/hypothalamic-expression-mutant-huntingtin-contributes-development-depressive-behavior-bac-transgenic - 2025-12-25

Linda Holmquist Mengelbier, PhD

Linda Holmquist Mengelbier is a paediatric cancer researcher who now, in parallel to her cancer effort, has started to work with the neurodegenerative disorders Huntington disease and ALS. Her focus in the cancer field has been on the embryonal pediatric solid tumors neuroblastoma and Wilms tumor. Neuroblastoma is a sympathetic nervous system tumor derived from the neural crest, whereas Wilms tumo

https://www.huntington-research.lu.se/team/linda-holmquist-mengelbier-phd - 2025-12-25

Mutant huntingtin expression in the hypothalamus promotes ventral striatal neuropathology

Soylu-Kucharz R, Adlesic N, Davidsson M, Björklund T, Björkqvist M and Petersén Å. bioRxiv 2023.03.04.530949; First published March 4, 2023, https://doi.org/10.1101/2023.03.04.530949 Abstract Huntington’s disease is a fatal neurodegenerative disorder caused by an expanded CAG triplet repeat in the huntingtin (HTT) gene. Previous research focused on neuropathology in the striatum and its associatio

https://www.huntington-research.lu.se/mutant-huntingtin-expression-hypothalamus-promotes-ventral-striatal-neuropathology - 2025-12-25

Attenuated huntingtin gene CAG nucleotide repeat size in individuals with Lynch syndrome

Dalene Skarping K, Arning L, Petersén Å, Nguyen HP and Gebre-Medhin S.Sci Rep. 2024;14(1):4300. Published 2024 Feb 21. doi:10.1038/s41598-024-54277-5AbstractDNA mismatch repair (MMR) is thought to contribute to the onset and progression of Huntington disease (HD) by promoting somatic expansion of the pathogenic CAG nucleotide repeat in the huntingtin gene (HTT). Here we have studied constitutional

https://www.huntington-research.lu.se/attenuated-huntingtin-gene-cag-nucleotide-repeat-size-individuals-lynch-syndrome - 2025-12-25

Ethical aspects of undergoing a predictive genetic testing for Huntington’s disease

Lilja Andersson P, Juth N, Petersén Å, Graff C and Edberg AE.Lund University, Sweden.Nursing Ethics 20: 189-199 (2013)AbstractThe aim of this study was to describe the experiences of undergoing a presymptomatic genetic test for the hereditary and fatal Huntington’s disease, using a case study approach. The study was based on 18 interviews with a young woman and her husband from the decision to und

https://www.huntington-research.lu.se/ethical-aspects-undergoing-predictive-genetic-testing-huntingtons-disease - 2025-12-25

Jennifer Oraha, PhD student

In 2024, Jennifer moved from Sydney, Australia to Lund, Sweden to start her PhD studies at the TNU, supervised by Pof. Åsa Petersén. In utilizing novel AAV-vectors and crossbreeding of animal models, Jennifer’s project aims to elucidate the specific hypothalamic circuitries important for the control of metabolism and emotion, with relevance to Huntington’s Disease, Amyotrophic Lateral Sclerosis an

https://www.huntington-research.lu.se/team/jennifer-oraha-phd-student - 2025-12-25

Expression of Mutant Huntingtin in Leptin Receptor-Expressing Neurons Does Not Control the Metabolic and Psychiatric Phenotype of the BACHD Mouse

Lundh SH, Soylu R and Petersén Å.Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.PLoS ONE 7(12): e51168 (2012).AbstractMetabolic and psychiatric disturbances occur early on in the clinical manifestation of Huntington’s disease (HD), a neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin (HTT) gene. Hypot

https://www.huntington-research.lu.se/expression-mutant-huntingtin-leptin-receptor-expressing-neurons-does-not-control-metabolic-and - 2025-12-25

For Better or for Worse: Lifeworld, System and Family Caregiving for a Chronic Genetic Disease

Hagen N, Lundin S, O'Dell T and Petersén Å.Culture Unbound 4: 537-557 (2012)AbstractModernity has meant a cultural and social differentiation within the western socie- ty, which, according to Jürgen Habermas’ theory on communication, can be seen as a division between different forms of actions that takes place in different realms of the society. By combining Habermas’ notions of lifeworld and sys

https://www.huntington-research.lu.se/better-or-worse-lifeworld-system-and-family-caregiving-chronic-genetic-disease - 2025-12-25

TDP-43 overexpression in the hypothalamus drives neuropathology, dysregulates metabolism and impairs behavior in mice

Bergh S, Casadei N, Gabery S, Simonsson O,  Duarte JMN, Kirik D, Nguyen HP and Petersén Å.Acta Neuropathologica Communications. 2025;13(1):119. Published 2025 May 27. doi:10.1186/s40478-025-02018-8AbstractTAR DNA-binding protein 43 (TDP-43) pathology is linked to the neurodegenerative disorders amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Huntington disease (HD). Dysregul

https://www.huntington-research.lu.se/tdp-43-overexpression-hypothalamus-drives-neuropathology-dysregulates-metabolism-and-impairs - 2025-12-25